[Title page]

The following topics are dealt with: bimodal TWMPI-MRI hybrid scanner - first NMR results; in vivo and ex vivo experimental MPI angiography with high selection field strength and tailored SPIO nanoparticles; analyzing dynamic processes from the raw magnetic particle measurement signal; first 3D dual modality phantom measurement of a hybrid MPI-MRI system using a resistive 12 channel MPI-MRI magnet design; local compression of the magnetic particle imaging system matrix for efficient image reconstruction; investigations on the robustness of particle separation in multicolor magnetic particle imaging; preliminary experimental X-space color MPI; magnetic particle imaging using the viscosity-dependent brownian particle response; reshaping the 2D MPI PSF to be isotropic and sharp using vector acquisition and equalization; high resolution magnetic particle imaging with low density trajectory; imaging and quantification of SPIONs for cancer therapy with magnetic drug targeting; traveling wave MPI goes pre-clinical application; encapsulation of new ferucarbotran nanoparticles into red blood cells as potential MPI contrast agent; in situ and ex vivo MPI performance compared to fluorescent and MRI imaging; SPIO requirements for in vivo sentinel lymph node localization; online coupling of hydrodynamic fractionation with DLS, MALLS and MPS for MPI tracer evaluation; magnetic particle spectroscopy of glioma cells targeted with lactoferrin-conjugated iron oxide nanoparticle contrast agents; effect of immobilisation of magnetic nanoparticles on MPS-signal; Zero Dead Time Rotational Drift Spectroscopy for magnetic particle ensembles; AC-susceptometry of magnetic nanoparticles using an atomic RF magnetometer; characterizing the imaging performance of magnetic tracers by magnetic particle spectroscopy in an offset field; magnetic particle spectroscopy to monitor the behavior of magnetic nanoparticles in different physiological media; SPIO-coating of devices for MPI-guided cardiovasc- lar interventions: proof of principle; changes in the behavior of magnetic iron oxide nanoparticles during cellular uptake detected by magnetic particle spectroscopy; hardware implementation of a 1d MPI hybrid system for targeted drug delivery; tunable in vivo circulation characteristics of PEGylated MPI tracers; effective uniaxial anisotropy in optimized magnetite MPI tracers probed by freezing in a magnetic field;formation of defined SPIO clusters by continuous flow encapsulation; phase-pure iron oxide nanoparticle MPI tracers: comparison of alternative thermal decomposition synthesis strategies; formation of a biocompatible protein corona on magnetic nanoparticles;gram scale synthesis of magnetite nanoparticles optimized for single-core MPI tracers; simultaneous patch reconstruction in magnetic particle imaging; computationally efficient image reconstruction via optimization for X-space MPI; focus field based trajectory elongation in MPI; resolution improvement by decreasing the drive field amplitude; undersampling the system matrix of a single sided MPI-scanner; performance and safety evaluation of a human sized ffl imager concept; preliminary characterization of a laminated iron-core 6.3 t/m ffl magnet; 2d imaging with a single-sided MPI device; simulation study of a novel relaxometer shield design; MPI with a mechanically rotated FFL; a custom low-noise preamplifier for magnetic particle imaging; and sensitivity and dynamic range improvement in MPI by means of a differential detection system.