Effect of immobilisation of magnetic nanoparticles on MPS-signal

How immobilization of MPI tracers changes the MPS-signal? To address this question we immobilized a sample with single core and a sample with multicore magnetic nanoparticles (MNP) in different matrices. In order to catch a possible effect of dipolar interaction between MNP, here we focus on large, high performing MNP which are preferable for MPI. The knowledge, how the immobilization affects MPS amplitude as well as MPI performance is important for the measurement of quantitative distribution of tracers (quantitative imaging) and for proper quantification of them by MPS, e.g. in cells and in MPS-based binding assays.