Formation of defined SPIO clusters by continuous flow encapsulation

Summary form only given. This paper presents the latest results in the development of optimized contrast agents for magnetic particle imaging (MPI) measurements using superparamagnetic iron oxide nanoparticles and the continuous flow phase transfer approach as described above. To yield a contrast agent with an increased MPI contrast we have developed a strategy to fill these capsules with a defined number of iron oxide particles using different mixers and surface ligands. We will show clusters with single particle sizes ranging from 5 to 15 nm and an overall hydrodynamic diameter between 50 and 200 nm to determine the optimal cluster size for MPI.