Title :
Role of macrophages in SPIO processing in lymphatic tissue — Further development of the breast cancer SNLB-concept using MPI
Author :
Finas, D. ; Stegmann-Frehse, J. ; Sauer, B. ; Huttmann, Gereon ; Rody, A. ; Buzug, T. ; Ludtke-Buzug, K.
Author_Institution :
Dept. of Obstetrics & Gynecology, Evangelical Hosp. Bielefeld, Bielefeld, Germany
Abstract :
Poor knowledge exists for enrichment of SPIOs in cells and individuals. Processing of SPIOs is therefore of major interest for the concept of sentinel lymph node detection for sentinel lymph node biopsy (SNLB) with nanoparticles in breast cancer patients. An accurate 3D detection of sentinel lymph node (SNL) by the use of superparamagnetic iron oxide nanoparticles (SPIO) and their representation by means of magnetic particle imaging (MPI) is possible to increase QoL. Therefore this work focuses on the development of this concept through evaluation of the organic tracer processing and safety for patients.
Keywords :
biomedical imaging; cancer; cellular biophysics; iron compounds; magnetic particles; nanomagnetics; nanomedicine; nanoparticles; superparamagnetism; 3D sentinel lymph node detection; FeO; SPIO processing; breast cancer SNLB-concept development; lymphatic tissue; macrophage; magnetic particle imaging; organic tracer processing evaluation; sentinel lymph node biopsy; superparamagnetic iron oxide nanoparticle; Breast cancer; Iron; Lymph nodes; Mice; Nanoparticles; Transmission electron microscopy;
Conference_Titel :
Magnetic Particle Imaging (IWMPI), 2015 5th International Workshop on
Conference_Location :
Istanbul
Print_ISBN :
978-1-4799-7269-2
DOI :
10.1109/IWMPI.2015.7107041
