Title :
RBF-based receding horizon control approach to personalized anemia treatment
Author :
Mirinejad, Hossein ; Inanc, Tamer ; Brier, Michael E. ; Gaweda, Adam E.
Author_Institution :
Dept. of Electr. & Comput. Eng., Univ. of Louisville, Louisville, KY, USA
Abstract :
A receding horizon controller is proposed as a means to personalize anemia management in hemodialysis patients. The proposed method is an optimization-based control approach in which a radial basis function (RBF) method is used to design a receding horizon strategy for optimal dosing of anemia drug, erythropoietin (EPO). The in silico validation of the method demonstrates its efficiency when compared to a standard protocol-based EPO dosing.
Keywords :
diseases; drugs; medical control systems; optimisation; patient treatment; radial basis function networks; RBF-based receding horizon control approach; erythropoietin; hemodialysis patients; optimal anemia drug dosing; optimization-based control approach; personalized anemia treatment; radial basis function method; Diseases; Drugs; Kidney; Optimal control; Predictive control; Protocols; Standards; RBF method; Receding horizon control; drug dosing; erythropoietin (EPO); personalized anemia treatment;
Conference_Titel :
Biomedical Engineering Conference (NEBEC), 2015 41st Annual Northeast
Conference_Location :
Troy, NY
Print_ISBN :
978-1-4799-8358-2
DOI :
10.1109/NEBEC.2015.7117064
