Title :
Enzyme loaded poly(lactic-co-glycolic acid) nanoparticles as anti-biofilm treatment strategy for chronic biofilm infections
Author :
Chendong Han ; Goodwine, James S. ; Romero, Nicholas ; Dookran, Julia ; Sauer, Karin ; Doiron, Amber L.
Author_Institution :
Dept. of Biomed. Eng., Binghamton Univ., Binghamton, NY, USA
Abstract :
The enzyme responsible for depleting a key metabolite required by biofilms, was encapsulated into poly(lactic-co-glycolic acid) PLGA nanoparticles in order to develop an adjunctive anti-biofilm treatment therapy.
Keywords :
antibacterial activity; biochemistry; drug delivery systems; encapsulation; enzymes; materials preparation; nanofabrication; nanomedicine; nanoparticles; polymer films; PLGA; adjunctive antibiofilm treatment therapy; chronic biofilm infections; encapsulation; enzyme loaded poly(lactic-co-glycolic acid) nanoparticles; metabolite; Biochemistry; Drug delivery; Encapsulation; In vitro; Microorganisms; Nanoparticles; Scanning electron microscopy;
Conference_Titel :
Biomedical Engineering Conference (NEBEC), 2015 41st Annual Northeast
Conference_Location :
Troy, NY
Print_ISBN :
978-1-4799-8358-2
DOI :
10.1109/NEBEC.2015.7117094
