Optimizing retinal ganglion cell responses to high-frequency electrical stimulation strategies for preferential neuronal excitation

Author

Tianruo Guo ; Lovell, Nigel H. ; Tsai, David ; Twyford, Perry ; Fried, Shelley ; Morley, John W. ; Suaning, Gregg J. ; Dokos, Socrates

Author_Institution

Grad. Sch. of Biomed. Eng., UNSW Australia, Sydney, NSW, Australia

fYear

2015

fDate

22-24 April 2015

Firstpage

252

Lastpage

255

Abstract

A retinal ganglion cell (RGC) model based on accurate biophysics and detailed representations of cell morphologies was used to understand how these cells respond to electrical stimulation over a wide range of frequencies, spanning 50-2000 pulses per second (PPS). Our modeling results and associated in vitro data both suggest the usefulness of high stimulation frequency in effectively modulating the activity of RGCs. This model can be used for optimizing varied extracellular stimulus profiles, and to assist in the design of sophisticated stimulation strategies for clinical visual neuroprostheses.

Keywords

bioelectric phenomena; cellular biophysics; eye; neurophysiology; RGC; biophysics; cell morphology; clinical visual neuroprostheses; extracellular stimulus profiles; high-frequency electrical stimulation; in vitro data; preferential neuronal excitation; retinal ganglion cell model; retinal ganglion cell responses; Adaptation models; Biological system modeling; Computational modeling; Electrical stimulation; Extracellular; Mathematical model; Retina;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering (NER), 2015 7th International IEEE/EMBS Conference on

Conference_Location

Montpellier

Type

conf

DOI

10.1109/NER.2015.7146607

Filename

7146607