Title :
Optimizing retinal ganglion cell responses to high-frequency electrical stimulation strategies for preferential neuronal excitation
Author :
Tianruo Guo ; Lovell, Nigel H. ; Tsai, David ; Twyford, Perry ; Fried, Shelley ; Morley, John W. ; Suaning, Gregg J. ; Dokos, Socrates
Author_Institution :
Grad. Sch. of Biomed. Eng., UNSW Australia, Sydney, NSW, Australia
Abstract :
A retinal ganglion cell (RGC) model based on accurate biophysics and detailed representations of cell morphologies was used to understand how these cells respond to electrical stimulation over a wide range of frequencies, spanning 50-2000 pulses per second (PPS). Our modeling results and associated in vitro data both suggest the usefulness of high stimulation frequency in effectively modulating the activity of RGCs. This model can be used for optimizing varied extracellular stimulus profiles, and to assist in the design of sophisticated stimulation strategies for clinical visual neuroprostheses.
Keywords :
bioelectric phenomena; cellular biophysics; eye; neurophysiology; RGC; biophysics; cell morphology; clinical visual neuroprostheses; extracellular stimulus profiles; high-frequency electrical stimulation; in vitro data; preferential neuronal excitation; retinal ganglion cell model; retinal ganglion cell responses; Adaptation models; Biological system modeling; Computational modeling; Electrical stimulation; Extracellular; Mathematical model; Retina;
Conference_Titel :
Neural Engineering (NER), 2015 7th International IEEE/EMBS Conference on
Conference_Location :
Montpellier
DOI :
10.1109/NER.2015.7146607
