Improving the brain machine interface via multiple Tetramethyl Orthosilicate sol-gel coatings on microelectrode arrays

The failure of neurally implanted microelectrode arrays has been highly correlated with the foreign body response (FBR). In order to maintain high fidelity signaling across the brain machine interface, the FBR must be minimized. Multiple thin coatings of Tetramethyl Orthosilicate have the potential to reduce the acute FBR through their ability to release a model therapeutic drug for 4 to 10 days, their positive effects on electrode performance (e.g. a minimal change in impedance at 1kHz, less than 10%, and an increase in charge carrying capacity, up to 49%), and their low impact on device thickness.