Title :
Biological particle manipulation: An example of Jurkat enrichment
Author :
Altinagac, Emre ; Ozcan, Safiye Selen ; Genc, Yavuz ; Kizil, Huseyin ; Trabzon, Levent
Author_Institution :
Dept. of Nanosci. & Nanoengineering, Istanbul Tech. Univ., Istanbul, Turkey
Abstract :
Separation of microparticles and living cells are studied with computational and experimental methods. The flow behaviors of particles are modeled and simulated using COMSOL Multiphysics 4.3a software. Lab-on-a-chip devices having a Ti interdigitated electrode layer on a glass substrate and a PDMS microchannel are fabricated to investigate the most effective design for separating particles based on their sizes. Polystyrene particles in different diameters (3.2 μm and 9.8 μm) are used in our experiments and experiments with T-lymphocytes and B lymphoblasts are in progress.
Keywords :
bioMEMS; cellular transport; lab-on-a-chip; microchannel flow; microfabrication; polymers; separation; titanium; B lymphoblasts; COMSOL Multiphysics 4.3a software; Jurkat enrichment; PDMS microchannel; T-lymphocytes; Ti interdigitated electrode layer; biological particle manipulation; flow behaviors; glass substrate; lab-on-a-chip devices; living cells; microparticle separation; polystyrene particles; size 3.2 mum; size 9.8 mum; Biology; Dielectrophoresis; Electric fields; Electrodes; Force; Microchannels; Microfluidics; AC Dielectrophoresis; Lab-on-a-Chip; Microfluidics; Particle Separation;
Conference_Titel :
Nano/Micro Engineered and Molecular Systems (NEMS), 2015 IEEE 10th International Conference on
Conference_Location :
Xi´an
DOI :
10.1109/NEMS.2015.7147348
