Modeling and control of a semi-batch cooling seeded crystallizer

Author

Rachah, Amira ; Noll, Dominikus

Author_Institution

Inst. de Math., Univ. de Toulouse, Toulouse, France

fYear

2015

fDate

27-29 May 2015

Firstpage

1

Lastpage

6

Abstract

We present a mathematical model of semi-batch cooling seeded crystallization of α-lactose monohydrate. The crystallization dynamics are described by population, mass and energy balance equations including the phenomena of nucleation (crystal birth) and growth. After developing the model we present two optimal control studies, where control of temperature and feed rate are used to increase the number of particles in a given narrow target size range. We compare our results obtained by optimal control with those obtained by heuristic strategies as often recommended in the literature.

Keywords

batch processing (industrial); cooling; crystallisation; mathematical analysis; nucleation; optimal control; process control; α-lactose monohydrate; control studies; crystal birth; crystallization; energy balance equations; mathematical model; nucleation; semibatch cooling seeded crystallization; semibatch cooling seeded crystallizer control; semibatch cooling seeded crystallizer modeling; Cooling; Crystallization; Crystallizers; Feeds; Mathematical model;

fLanguage

English

Publisher

ieee

Conference_Titel

Modeling, Simulation, and Applied Optimization (ICMSAO), 2015 6th International Conference on

Conference_Location

Istanbul

Type

conf

DOI

10.1109/ICMSAO.2015.7152213

Filename

7152213