Title :
A novel high-sensitivity cardiac multi-biomarkers detecting system based on microfluidic chip and GMR sensor
Author :
Huo, W. ; Gao, Y. ; Zhang, L. ; Shi, S.
Author_Institution :
Key Lab. of Photochem. Conversion & Optoelectron. Mater., Tech. Inst. of Phys. & Chem., Beijing, China
Abstract :
Giant magnetoresistance (GMR) is a quantum mechanical magnetoresistance effect observed in thin-film structures composed of alternating ferromagnetic and non-magnetic conductive layers. Today GMR has been used in various fields including detecting DNA hybridization and pathogenic microorganism[1], screening diagnostic biomarkers[2], detecting HBV genotypes[3], and so on. NT-proBNP is an established risk factor in patients with heart failure or coronary disease. cTnI is considered the standard biomarker for acute myocardial infarction(AMI). The combined detection of NT-proBNP and cTnI could improve the sensitivity and specificity in clinical diagnosis of myocardial injury.
Keywords :
DNA; bioMEMS; biomedical equipment; cardiology; cellular biophysics; diseases; ferromagnetic materials; giant magnetoresistance; injuries; magnetic sensors; magnetic thin films; magnetoresistive devices; medical disorders; microfluidics; microorganisms; molecular biophysics; patient diagnosis; DNA hybridization; GMR sensor; NT-proBNP; alternating ferromagnetic conductive layers; clinical diagnosis; coronary disease; detecting HBV genotypes; heart failure; high-sensitivity cardiac multibiomarker detecting system; microfluidic chip; myocardial infarction; myocardial injury; nonmagnetic conductive layers; pathogenic microorganism; quantum mechanical magnetoresistance effect; risk factor; screening diagnostic biomarkers; standard biomarker; thin-film structures; Bonding; Calibration; Cavity resonators; Immune system; Microfluidics; Nanoparticles; Standards;
Conference_Titel :
Magnetics Conference (INTERMAG), 2015 IEEE
Conference_Location :
Beijing
Print_ISBN :
978-1-4799-7321-7
DOI :
10.1109/INTMAG.2015.7156941
