Title :
Biological immunoassay utilizing magnetoresistive sensor and magnetic-field-controlled binding between magnetic markers and targets
Author :
Noguchi, K. ; Sakakibara, T. ; Yoshida, T. ; Enpuku, K.
Author_Institution :
Kyushu Univ., Fukuoka, Japan
Abstract :
This research presents the development of a magnetic immunoassay technique using magnetic markers and magnetoresistive sensor for used in the liquid phase detection of biological targets. In this method, bound and free markers can be magnetically distinguished by using Brownian relaxation of magnetic markers, eliminating time consuming washing process for marker separation. Biotin molecules as targets and streptavidin-conjugated magnetic markers were used for detection.
Keywords :
Brownian motion; biological techniques; biomagnetism; biosensors; magnetic sensors; magnetoresistive devices; molecular biophysics; proteins; Brownian relaxation; biological immunoassay; biological targets; biotin molecules; liquid phase detection; magnetic immunoassay technique; magnetic-field-controlled binding; magnetoresistive sensor; streptavidin-conjugated magnetic markers; Immune system; Magnetic liquids; Magnetic moments; Magnetic separation; Nanoparticles; Noise;
Conference_Titel :
Magnetics Conference (INTERMAG), 2015 IEEE
Conference_Location :
Beijing
Print_ISBN :
978-1-4799-7321-7
DOI :
10.1109/INTMAG.2015.7157194
