Title :
Microwave hyperthermia versus nanosecond pulsed electric field for in vivo tumors applications
Author :
Soueid, M. ; Jacques, J. ; Yardin, C. ; Fontanier, S. ; O´Connor, R. ; Leveque, P. ; Arnaud-Cormos, D.
Author_Institution :
XLIM Res. Inst., Univ. of Limoges, Limoges, France
Abstract :
In this paper, two delivery systems based on microwave (MW) antenna and nsPEF electrodes employing, respectively, thermal and electrical effects for in vivo exposure of cancer tumors were characterized. To determine the efficiency of the devices, numerical and experimental electromagnetic dosimetry was performed. For the MW antenna, Specific Absorption Rate (SAR) distribution was evaluated in equivalent tissue at 2.45 GHz. The exposed zone for a SAR higher than 50 W/kg was around 1-cm in size. For the nsPEF system, the electric field distribution was studied with an applied pulse of 10-ns duration and an amplitude of 6.1 kV. The electric field intensity obtained between electrodes was 16 MV/m.
Keywords :
bioelectric phenomena; biomedical electrodes; cancer; dosimetry; hyperthermia; microwave antennas; nanomedicine; tumours; cancer tumors; delivery systems; electric field distribution; electrical effects; equivalent tissue; experimental electromagnetic dosimetry; frequency 2.45 GHz; in vivo tumors applications; microwave antenna; microwave hyperthermia; nanosecond pulsed electric field; nsPEF electrodes; nsPEF system; numerical electromagnetic dosimetry; specific absorption rate distribution; thermal effects; time 10 ns; Cable insulation; Coaxial cables; Dielectric measurement; Dielectrics; Microwave FET integrated circuits; Microwave devices; Microwave integrated circuits; Electrode-based delivery system; Electromagnetic characterization; Microwave ablation (MWA); Triaxial antenna; nanosecond Pulsed Electric Field (nsPEF);
Conference_Titel :
Microwave Symposium (IMS), 2015 IEEE MTT-S International
Conference_Location :
Phoenix, AZ
DOI :
10.1109/MWSYM.2015.7166998
