A compact NIR fluorescence imaging system with goggle display for intraoperative guidance

Author

Shengkui Gao ; Mondal, Suman ; Nan Zhu ; Rongguang Liang ; Achilefu, Samuel ; Gruev, Viktor

Author_Institution

Dept. of Comput. Sci. & Eng., Washington Univ. in St. Louis, St. Louis, MO, USA

fYear

2015

fDate

24-27 May 2015

Firstpage

1622

Lastpage

1625

Abstract

Near infra-red (NIR) fluorescence imaging offers high sensitivity and specificity for cancer detection and tumor margin localization. In this paper, a compact and wearable NIR fluorescence imaging system (FIS) for image guided surgery is presented. The proposed FIS captures 27 frames per second of both NIR and visible spectrum data, allowing for minimum detection of 10nM of ICG concentration. The design tradeoffs of the complete system are carefully analyzed. The performance of the proposed FIS is evaluated under both sensitivity test and experimental mouse study. The imaging system is currently used in clinical trials for imaging sentinel lymph nodes in breast cancer and melanoma patients.

Keywords

biological organs; biomedical optical imaging; cancer; eye protection; fluorescence; infrared spectra; surgery; visible spectra; FIS captures; ICG concentration; NIR spectrum data; breast cancer; cancer detection; compact NIR fluorescence imaging system; goggle display; image guided surgery; intraoperative guidance; melanoma patients; near infrared fluorescence imaging; sensitivity test; sentinel lymph nodes; tumor margin localization; visible spectrum data; wearable NIR fluorescence imaging system; CMOS integrated circuits; Fluorescence; Image color analysis; Imaging; Light sources; Surgery; CMOS imaging sensor; NIR fluorescence imaging; image guided surgery; sensor system; wearable device;

fLanguage

English

Publisher

ieee

Conference_Titel

Circuits and Systems (ISCAS), 2015 IEEE International Symposium on

Conference_Location

Lisbon

Type

conf

DOI

10.1109/ISCAS.2015.7168960

Filename

7168960