Pathogenic bacteria detection based-CBCM on MLoC and nano-amplification strategy

Human pathogenic bacteria disease is a worldwide pervasive disease. It kills more than two million people yearly, therefore, pathogenic disease is the highest disease burden as its rank is one out of four main diseases that threaten human lives. Pathogenic disease contributes to other worldwide severe diseases, such as pneumonia and causes infections such as typhoid fever, which is difficult to control at late stages. This work presents a CMOS biosensor based CBCM system that uses phage organisms to detect bacteria for different applications. The system provides a viable alternative to traditional growth-based bacterial analysis systems, which are time consuming. The system employs an interdigitated capacitor structure, charge based capacitance measurement circuitry to detect, and process capacitance changes in the presence of targeted bacteria. In this work, we concentrate on capacitive biosensor as a part of multi-labs-on-a single chip (MLoC) realized through CMOS technology.