A mcirofluidic device of biodegradable porous silicon nanowires for size based capturing and releasing viruses

Author

Yiqiu Xia ; Si-Yang Zheng

Author_Institution

Dept. of Biomed. Eng., Pennsylvania State Univ., University Park, PA, USA

fYear

2015

fDate

21-25 June 2015

Firstpage

444

Lastpage

447

Abstract

A microfluidic device of porous silicon nanowire (PSNW) channel walls was fabricated as a point-of-care platform to capture nanoparticles (NPs) like viruses based on their sizes. PSNWs were synthesized on the bottom and sidewalls of the micro channels with metal-assisted etching. The space between PSNWs was controlled to capture NPs with a specific size. To enhance the capture rate, meandering channels were designed to increase the interaction between NPs and PSNWs by the Dean flow. With this system, we demonstrated label-free N5H2 avian influenza virus capture. In addition, virus can be released later and collected at the outlet by degrading PSNWs in PBS for 24 hours.

Keywords

bioMEMS; biodegradable materials; biomedical equipment; biomedical measurement; diseases; etching; materials preparation; microchannel flow; microfabrication; microorganisms; nanofabrication; nanoparticles; nanowires; particle size; patient care; porous materials; silicon; Dean flow; NP capture rate enhancement; NP size; NP-PSNW interaction; PBS; PSNW channel wall; PSNW degradation; PSNW space control; PSNW synthesis; Si; biodegradable porous silicon nanowire; label-free N5H2 avian influenza virus capture; mcirofluidic device fabrication; meandering channel design; metal-assisted etching; microchannel; nanoparticle capture; point-of-care platform; size based virus capturing; size based virus releasing; time 24 hour; virus collection; Etching; Fabrication; Fluorescence; Influenza; Microfluidics; Nanowires; Silicon; Dean flow; Microfluidic device; label-free capture; porous silicon nanowire;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on

Conference_Location

Anchorage, AK

Type

conf

DOI

10.1109/TRANSDUCERS.2015.7180956

Filename

7180956