An ultrasonically powered implantable micro-light source for localized photodynamic therapy

Author

Zhou, J. ; Kim, A. ; Song, S.H. ; Ziaie, B.

Author_Institution

Birck Nanotechnol. Center, Purdue Univ., West Lafayette, IN, USA

fYear

2015

fDate

21-25 June 2015

Firstpage

876

Lastpage

879

Abstract

In this work, we introduce an ultrasonically powered light source which can provide in situ localized light for photodynamic therapy. The implants are 2×2×2 mm³ and 2×4×2 mm³ in dimensions and consist of two red LEDs mounted on a piezoelectric energy source. Such device is small enough to be easily implanted inside solid tumors using a biopsy needle. In vitro light intensity measurements show an output power density of 48 μW/cm² from the 2×2×2 mm³ and 1.1 mW/cm² from the 2×4×2 mm³ light source. The results indicate that implanting multiple sources and powering them for 1 hour can provide optimal energy for localized photodynamic therapy.

Keywords

light emitting diodes; light sources; photodynamic therapy; piezoelectric devices; prosthetics; tumours; biopsy needle; in vitro light intensity measurements; localized photodynamic therapy; piezoelectric energy source; red LEDs; tumors; ultrasonically powered implantable microlight source; Acoustics; In vitro; Light emitting diodes; Light sources; Medical treatment; Receivers; Tumors; Piezoelectric; micro light source; photodynamic therapy; ultrasonic powering;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on

Conference_Location

Anchorage, AK

Type

conf

DOI

10.1109/TRANSDUCERS.2015.7181063

Filename

7181063