Implantable enzyme free glucose sensor based on flexible stainless steel for continuous monitoring and mass production

In this study, implantable and flexible enzyme free glucose sensor was developed by using thin medical grade stainless steel for continuous glucose monitoring and mass production. Unlike conventional polymer substrate, a thin stainless steel based sensing electrode has large effective surface area and small difference in the coefficient of thermal expansion between the substrate and electrode. Furthermore, electroplating technique was useful for the mass production of sensor due to simple fabrication steps. The fabricated glucose sensor exhibited the sensitivity of 1 μA/mM and response time of 15 s. In addition, it also showed a good current response to glucose in human plasma with the sensitivity of 0.45 μA/mM and correlation coefficient of 0.94071.