• DocumentCode
    73252
  • Title

    Quantum-Dot-Based Aptamer Beacons for {\\rm K}^{+} Detection

  • Author

    Tsai-Chin Wu ; Guijun Zhao ; Hui Lu ; Dutta, Maitreyee ; Stroscio, Michael A.

  • Author_Institution
    Bioeng. Dept., Univ. of Illinois, Chicago, IL, USA
  • Volume
    13
  • Issue
    5
  • fYear
    2013
  • fDate
    May-13
  • Firstpage
    1549
  • Lastpage
    1553
  • Abstract
    Herein, aptamer-based quantum-dot detectors of K+ made of two-different K+ aptamers are compared. These deoxyribonucleic acid-based aptamers are TBA (5´ GGT TGG TGT GGT TGG 3´) and AG3 ( 5´ GGG TTA GGG TTA GGG TTA GGG 3´ ). The nanoscale aptamer-quantum-dot-based detectors described in this paper are synthesized and tested in DI water aliquots that contain KCl. The results including data suggest that beacons made of AG3 and TBA serve better as an ion indicator in different potassium level regions. As a result, aptamer beacon made of AG3 has better potential in the design of take-home diagnostic devices for hyperkalemia and hypokalemia.
  • Keywords
    DNA; biomedical equipment; biosensors; diseases; nanosensors; quantum dots; DI water aliquots; K+ aptamers; K+ detection; TBA; aptamer-based quantum-dot detectors; deoxyribonucleic acid-based aptamers; hyperkalemia; hypokalemia; ion indicator; nanoscale aptamer-quantum dot-based detectors; quantum dot-based aptamer beacons; take-home diagnostic device design; Biomedical equipment; DNA; Diseases; Fluorescence; Ions; Quantum dots; Aptamer; deoxyribonucleic acid; molecular beacon; nanotechnology; potassium ion; quantum dot; tetraplex; thrombin-binding aptamer;
  • fLanguage
    English
  • Journal_Title
    Sensors Journal, IEEE
  • Publisher
    ieee
  • ISSN
    1530-437X
  • Type

    jour

  • DOI
    10.1109/JSEN.2012.2229387
  • Filename
    6359742