Silanization using APTES in different solvents on titanium dioxide nanoparticles

This Detection of specific biomolecules increases interest in the development of biosensor especially for its applicability and complexity. Biomolecules and nanomaterials are the two issues that researchers used to improve electrical signal originating from biochemical reactions. Titanium dioxide nanoparticles (TiO2) on aluminium electrodes-based DNA biosensor were fabricated using conventional photolithography. This device rapidly response since the data comes out quantitatively In order to create a chemical reaction between DNA and the nanoparticles surface, a surface treatment process has been done namely silanization. APTES is used as a coupling agent of TiO2 towards DNA as DNA cannot be directly bonded with the TiO2 surface. Hence, surface modification using APTES diluted in different solvents for further DNA detection is studied. Only certain solvents are suitable to be diluted with APTES and able to generate conductivity. Hence, the conductivity was measured to identify the reaction between the APTES and TiO2 nanoparticles. APTES diluted in acetone gives unreadable conductivity.