Oligostilbenoids Investigation of Structure-Activity Relationship with Chemical Biology Information

The present study was to isolate oligostilbenoids with anti-MRSA activity from the seed cake of Paeonia in Luoyang, China. In the screening program for natural bioactive compounds that enhance the expression of a minimal inhibitory concentration (MIC) value of the tested compounds against Methicillin-resistant staphylococcus aureus, and the exploration of their structure-activity relationship. The MIC of the purified molecule Gnetin H was 0.059mg/mL and Trans-?-viniferin was 0.118mg/mL. Activity-guided fractionation of the seed cake of Paeonia EtOAc extract led to the isolation of three oligostilbenoids (1-3), and revealed the antibacterial activity of stilbenoids associated with the structure of phenol polymerization degree.