DocumentCode
736925
Title
Oligostilbenoids Investigation of Structure-Activity Relationship with Chemical Biology Information
Author
Li, Haidi ; Yin, Weiping ; Liu, Pu ; Liu, Huaqing
fYear
2015
fDate
13-14 June 2015
Firstpage
716
Lastpage
718
Abstract
The present study was to isolate oligostilbenoids with anti-MRSA activity from the seed cake of Paeonia in Luoyang, China. In the screening program for natural bioactive compounds that enhance the expression of a minimal inhibitory concentration (MIC) value of the tested compounds against Methicillin-resistant staphylococcus aureus, and the exploration of their structure-activity relationship. The MIC of the purified molecule Gnetin H was 0.059mg/mL and Trans-?-viniferin was 0.118mg/mL. Activity-guided fractionation of the seed cake of Paeonia EtOAc extract led to the isolation of three oligostilbenoids (1-3), and revealed the antibacterial activity of stilbenoids associated with the structure of phenol polymerization degree.
Keywords
Antibacterial activity; Chemicals; Microorganisms; Microwave integrated circuits; Silicon compounds; Methicillin-resistant staphylococcus aureus; antibacterial activity; cis-?-viniferin; gnetin H; seed cake of Paeonia; trans-?-viniferin;
fLanguage
English
Publisher
ieee
Conference_Titel
Measuring Technology and Mechatronics Automation (ICMTMA), 2015 Seventh International Conference on
Conference_Location
Nanchang, China
Print_ISBN
978-1-4673-7142-1
Type
conf
DOI
10.1109/ICMTMA.2015.178
Filename
7263672
Link To Document