The Component Analysis of Propofol and Etomidate Mixture and Its Clinical Efficacy

At present, medication safety is the key event in hospital. This paper discusses the pharmacy stability of propofol and etomidate mixture and its clinical efficacy in combination. In order to solve the problem efficiently, we adopt a high performance liquid chromatography(HPLC)and a nuclear magnetic resonance spectroscopy(NMR) to determinate the stability of propofol and etomidate mixture fristly. Then 120 patients of early pregnancy undergoing abortion surgeries were randomly assigned to propofol group(P group), etomidate group(E group) and propofol + etomidate group(EP group). Patients in P group were induced with 1% propofol 15ml. In E group, Patients were induced with 0.2% etomidate 15ml. In EP group, induction was performed with 1% propofol 10ml and 0.2% etomidate 5ml. To compare the results of hemodynamics, injection pain, myoclonus and recovery time among groups. As a results, the comparision of HPLC and H1-NMR showed nice chemical stability of samples. EP group has obvious advantages.