DocumentCode :
737826
Title :
PVC-Membrane Potentiometric Sensor for the Determination of Tamoxifen in Pharmaceutical Formulations
Author :
Kanberoglu, Gulsah Saydan ; Coldur, Fatih ; Topcu, Cihan ; Cubuk, Osman
Author_Institution :
Dept. of Chem., Yuzuncu Yil Univ., Van, Turkey
Volume :
15
Issue :
11
fYear :
2015
Firstpage :
6199
Lastpage :
6207
Abstract :
Novel tamoxifen-selective potentiometric electrodes based on various ion associations of tamoxifen were developed. The most suitable membrane composition, which has the best potentiometric characteristics, was examined under steady-state conditions. The membrane composed of (w/w) 3% tamoxifenphosphomolibdate ion pair, 32% poly(vinylchloride), and 65% 2-nitrophenyloctylether was determined as the membrane with the best analytical properties. On the condition of pH = 2-6, the fabricated electrode exhibited linear responses over the concentration range of 9.1 × 10-6 -1 × 10-3 M tamoxifen solutions (R2 = 0.9989) with a sensitivity of 42.9 ± 0.3 mV/decade, detection limit of 7.3 ± 0.4 × 10-6 M and short response time of ≈25 s. The influences of some alkaline, alkaline earth metals, biologically significant molecules, and some pharmaceutical species over electrode responses were studied. The proposed electrode was applied for the determination of tamoxifen contents of some pharmaceutical formulations by using standard addition method. The potentiometric analysis results obtained for the pharmaceutical formulations were in good harmony with the results obtained by high performance liquid chromatography at 95% confidence level.
Keywords :
biomembranes; biosensors; chromatography; drugs; pH; polymers; potentiometers; 2-nitrophenyloctylether; PVC-membrane potentiometric sensor; alkaline earth metals; alkaline metals; analytical properties; high performance liquid chromatography; ion associations; membrane composition; pH; pharmaceutical formulations; pharmaceutical species; poly(vinylchloride); potentiometric analysis; steady-state conditions; tamoxifen determination; tamoxifen solutions; tamoxifen-phosphomolibdate ion pair; tamoxifen-selective potentiometric electrodes; Calibration; Drugs; Electric potential; Electrodes; Sensors; Time factors; Drug analysis; Ion-selective electrode; Tamoxifen determination; ion-selective electrode; potentiometry; tamoxifen determination;
fLanguage :
English
Journal_Title :
Sensors Journal, IEEE
Publisher :
ieee
ISSN :
1530-437X
Type :
jour
DOI :
10.1109/JSEN.2015.2454053
Filename :
7152821
Link To Document :
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