Title :
First-pass angiography in mice using FDG-PET: a simple method of deriving the cardiovascular transit time without the need of region-of-interest drawing
Author :
Wu, Hsiao-Ming ; Kreissl, Michael C. ; Schelbert, Heinrich R. ; Ladno, Waldemar ; Prins, Mayumi ; Shoghi-Jadid, Kooresh ; Chatziioannou, Arion ; Phelps, Michael E. ; Huang, Sung-Cheng
Author_Institution :
Dept. of Molecular & Med. Pharmacology, David Geffen Sch. of Med., Los Angeles, CA, USA
Abstract :
In this study, we developed a simple and robust semi-automatic method to measure the right ventricle to left ventricle (RV-to-LV) transit time (TT) in mice using 2-[18F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET). The accuracy of the method was first evaluated using a 4-D digital dynamic mouse phantom. The RV-to-LV TTs of twenty-nine mouse studies were measured using the new method and compared to those obtained from the conventional ROI-drawing method. The results showed that the new method correctly separated different structures (e.g., RV, lung, and LV) in the PET images and generated corresponding time activity curve (TAC) of each structure. The RV-to-LV TTs obtained from the new method and ROI method were not statistically different (p=0.20; r=0.76). We expect that this fast and robust method is applicable to the pathophysiology of cardiovascular diseases using small animal models such as rats and mice.
Keywords :
angiocardiography; cardiovascular system; phantoms; positron emission tomography; 4-D digital dynamic mouse phantom; FDG-PET; PET images; cardiovascular diseases; cardiovascular transit time; conventional ROI-drawing method; first-pass angiography; left ventricle; lung; mice; pathophysiology; positron emission tomography; rats; right ventricle; robust semiautomatic method; small animal models; Angiography; Cardiology; Image generation; Imaging phantoms; Lungs; Mice; Positron emission tomography; Robustness; Speech synthesis; Time measurement; Cardiovascular transit time; first-pass angiography; mice; positron emission tomography;
Journal_Title :
Nuclear Science, IEEE Transactions on
DOI :
10.1109/TNS.2005.858239