Title :
A 3-D Finite Element Poisson–Nernst–Planck Model for the Analysis of Ion Transport Across Ionic Channels
Author :
Coco, Salvatore ; Gazzo, Daniela ; Laudani, Antonino ; Pollicino, Giuseppe
Author_Institution :
DIEES, Catania Univ.
fDate :
4/1/2007 12:00:00 AM
Abstract :
A 3-D finite element steady-state Poisson-Nernst-Planck model is presented and applied to the analysis of the ion transport across ionic channels of the cellular membrane. The model allows us to obtain an accurate description of ion flow across the cell membrane. An example of application to the case of a K+ channel is also illustrated. The resulting current-voltage relationship for the K+ channel shows excellent agreement with experimental measurements
Keywords :
Poisson equation; biomembrane transport; finite element analysis; 3D finite element Poisson-Nernst-Planck model; K+ channel; cell membranes; cellular membranes; current-voltage relationship; ion flows; ion transport analysis; ionic channels; steady-state model; Atomic measurements; Biomembranes; Cells (biology); Finite element methods; Geometry; Mathematical model; Microscopy; Poisson equations; Steady-state; Stochastic processes; Finite element method; Poisson–Nernst–Planck model; ion transport; membrane ionic channel;
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2007.891402
