Title :
Finite-Element Modeling of Cell Exposed to Harmonic and Transient Electric Fields
Author :
Meny, I. ; Burais, N. ; Buret, F. ; Nicolas, L.
Author_Institution :
Ecole Centrale de Lyon, Ecully
fDate :
4/1/2007 12:00:00 AM
Abstract :
The transmembrane potential (TMP) of a cell exposed to harmonic or transient electric fields is the main parameter for a successful permeabilization of a cell. Obviously, TMP can be computed with a finite-element method, but the high contrast between sizes and electromagnetic properties of the cytoplasm, the membrane, and the extra-cellular medium leads sometimes to inaccurate numerical results. Influences of membrane conductivity and frequency on the accuracy are studied. Optimization of transient waveforms is proposed for various shapes of cells
Keywords :
electric fields; electromagnetism; finite element analysis; transient analysis; cytoplasm electromagnetic properties; extra cellular medium; finite element modelling; harmonic electric fields; membranes conductivity; transient electric fields; transient waveforms; transmembrane potential; Biomembranes; Cells (biology); Conductivity; Electromagnetic transients; Finite element methods; Frequency; Geometry; Shape; Solid modeling; Voltage; Bioelectric phenomena; biological cells; electromagnetic field computing; finite-element method (FEM);
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2007.892517
