Development of a real-time algorithm for predicting sufentanil plasma levels during cardiopulmonary-bypass surgery, using a systems approach

Author

Liu, M.-Z. ; Silvern, D.A. ; Gupte, P.M. ; Inchiosa, M.A., Jr. ; Sanchala, V.

Author_Institution

Westchester County Med. Center, Valhalla, NY, USA

Volume

39

Issue

6

fYear

1992

fDate

6/1/1992 12:00:00 AM

Firstpage

658

Lastpage

661

Abstract

A report on the development of a model for the computer-guided administration of sufentanil throughout surgical procedures involving cardiopulmonary-bypass (CB) is presented. The authors approach the effects of hypothermia on sufentanil clearance by applying a continuous temperature correction to the ultimate elimination rate constant (the terminal eigenvalue). This correction is based primarily on the anticipated effects of temperature on the enzyme-catalyzed reactions which are essential for the elimination of the drug from the body. An algorithm for the application of the model is also presented.

Keywords

cardiology; lung; physiological models; surgery; cardiopulmonary-bypass surgery; continuous temperature correction; drug elimination; enzyme-catalyzed reactions; real-time algorithm; sufentanil plasma levels prediction; systems approach; terminal eigenvalue; Biomedical engineering; Cardiology; Drugs; Electrodes; Light emitting diodes; Neurons; Plasmas; Prediction algorithms; Retina; Surgery; Algorithms; Anesthetics; Body Fluid Compartments; Cardiopulmonary Bypass; Fentanyl; Models, Biological; Sufentanil; Therapy, Computer-Assisted;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/10.141206

Filename

141206