DocumentCode :
757607
Title :
Planar Waveguides for Fluorescence-Based Biosensing: Optimization and Analysis
Author :
Bernini, Romeo ; Cennamo, Nunzio ; Minardo, Aldo ; Zeni, Luigi
Author_Institution :
IREA
Volume :
6
Issue :
5
fYear :
2006
Firstpage :
1218
Lastpage :
1226
Abstract :
Optimization of planar waveguides for fluorescence biosensing is presented in this paper. In particular, the authors show that optical (refractive index) and geometrical parameters have a strong influence on the efficiency of excitation and collection of fluorescent signals. Numerical analyses show that a single-mode slab waveguide, operating at its fundamental transverse magnetic mode and near its cutoff point, results in an efficient fluorescence excitation when employed as evanescent wave biosensor. A high-refractive index contrast is demonstrated to be the key parameter for an efficient fluorescence collection. Other geometries that are an alternative to the classical slab waveguide may result in an improvement of the fluorescence excitation and collection efficiencies
Keywords :
biosensors; fluorescence; optical sensors; optical waveguides; planar waveguides; refractive index; evanescent wave biosensor; fluorescence biosensor; fluorescence collection; fluorescence excitation; planar waveguides; refractive index; slab waveguide; transverse magnetic mode; Biomedical optical imaging; Biosensors; Fluorescence; Geometrical optics; Optical planar waveguides; Optical refraction; Optical surface waves; Optical waveguides; Planar waveguides; Slabs; Biosensors; fluorescence; optimization analysis; planar waveguides;
fLanguage :
English
Journal_Title :
Sensors Journal, IEEE
Publisher :
ieee
ISSN :
1530-437X
Type :
jour
DOI :
10.1109/JSEN.2006.881408
Filename :
1703481
Link To Document :
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