On-Chip Electrochemical Analysis System Using Nanoelectrodes and Bioelectronic CMOS Chip

Author

Zhu, Xiaoshan ; Ahn, Chong H.

Author_Institution

Dept. of Electr. & Comput. Eng., Cincinnati Univ., OH

Volume

6

Issue

5

fYear

2006

Firstpage

1280

Lastpage

1286

Abstract

An electrochemical microanalysis system for reversible redox species determination has been presented. This system consists of a nanoelectrochemical sensor and a complimentary metal-oxide-semiconductor (CMOS) chip for sensor signal interfacing and conditioning. The nanoelectrochemical sensor is an interdigitated array nanoelectrode fabricated using e-beam lithography and ultraviolet lithography. The CMOS chip is designed and fabricated to realize the electrochemical analysis method of sensing, which is a switch-based method. Using this switch-based method, the potential dynamics of the nanoelectrodes is recorded to evaluate the species concentration. Experimental results have shown that the detection limit of this microanalysis system on reversible redox species is in the range of 1-10 nM

Keywords

CMOS integrated circuits; electrochemical analysis; electrochemical sensors; nanoelectronics; CMOS chip; bioelectronic; e-beam lithography; electrochemical analysis system; interdigitated array nanoelectrode; nanoelectrochemical sensor; reversible redox species determination; sensor signal interfacing; signal conditioning; ultraviolet lithography; Biosensors; Circuits; Computer science; Electrodes; Laboratories; Lithography; Sensor arrays; Sensor systems; System-on-a-chip; Testing; Bioelectronic complimentary metal–oxide–semiconductor (CMOS) chip; electrochemical analysis; nanoelectrodes; reversible redox species;

fLanguage

English

Journal_Title

Sensors Journal, IEEE

Publisher

ieee

ISSN

1530-437X

Type

jour

DOI

10.1109/JSEN.2006.881351

Filename

1703489