Title :
Noninvasive localization of the site of origin of paced cardiac activation in human by means of a 3-D heart model
Author :
Li, Guanglin ; Zhang, Xin ; Lian, Jie ; He, Bin
Author_Institution :
Dept. of Bioeng., Univ. of Illinois, Chicago, IL, USA
Abstract :
A recently developed heart-model-based localization approach is experimentally evaluated in noninvasively localizing the site of origin of cardiac activation in a patient with a pacemaker. The heart-torso model of the patient was constructed from the contrast ultrafast computed tomography images. The site of initial paced activation in the patient was quantitatively localized and compared with the tip position of the pacemaker lead. The localization error of the inverse estimation was found to be 5.2 mm with respect to the true lead tip position. The promising result of this pilot experimental study suggests the feasibility of localizing the site of origin of cardiac activation in an experimental setting. The heart-model-based localization approach may become an alternative tool in localizing the site of origin of cardiac activation.
Keywords :
computerised tomography; inverse problems; pacemakers; physiological models; body surface potential map; cardiographic inverse problem; contrast ultrafast computed tomography images; heart-model-based localization approach; heart-torso model; initial paced activation site; inverse estimation; pace mapping; pacemaker lead tip position; Biomedical engineering; Computed tomography; Electrocardiography; Heart; Humans; Inverse problems; Myocardium; Pacemakers; Radio frequency; Smoothing methods; Aged; Algorithms; Arrhythmias, Cardiac; Body Surface Potential Mapping; Electric Stimulation Therapy; Electrodes, Implanted; Feasibility Studies; Heart Conduction System; Heart Ventricles; Humans; Male; Models, Cardiovascular; Neural Networks (Computer); Pacemaker, Artificial; Pilot Projects;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2003.816068
