Synthesis and Characterization of a Magnetic Nanoemulsion as a Promising Candidate for Cancer Treatment

Author

Macaroff, Patricia Pereira ; Primo, Fernando Lucas ; Bentes de Azevedo, R. ; Lacava, Zulmira Guerreiro Marques ; Morais, Paulo Cesar ; Tedesco, Antonio Claudio

Author_Institution

FFCLRP-USP, Univ. de Sao Paulo, Ribeirdao Preto

Volume

42

Issue

10

fYear

2006

Firstpage

3596

Lastpage

3598

Abstract

In this work, we performed the synthesis and characterization of a new class of drug delivery system denominated magnetic nanoemulsion (MNE), which allows the combined action of photodynamic therapy (PDT) and hyperthermia therapy (HPT), designed to work in a synergic way, leading to an expected enhancement of the tumor damage after minimum doses of heat dissipation and/or visible light photosensitization The MNEs were prepared by mixture of two surfactants among the following: Epikuron 170 or Span 80/Poloxamer 188 or Tween 80. The magnetic nanoparticles (MNPs) used in this study are maghemite surface-coated with phosphate (PPT) and the photosensitizer used is Zinc phthalocyanine derivative (ZnPc)

Keywords

cancer; hyperthermia; magnetic fluids; microemulsions; patient treatment; photochemistry; tumours; Epikuron 170; Poloxamer 188; Span 80; Tween 80; cancer treatment; drug delivery system; heat dissipation; hyperthermia therapy; light photosensitization; magnetic fluid; magnetic nanoemulsion; photodynamic therapy; photosensitizer; tumor damage; Biological tissues; Cancer; Drug delivery; Hyperthermia; Magnetic liquids; Medical treatment; Nanobioscience; Nanoparticles; Neoplasms; Zinc; Hyperthermia; magnetic fluid; magnetic nanoemulsion; photodynamic therapy; photosensitizer;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2006.879964

Filename

1704704