Title :
Magnetic Resonance and Light Microscopy Investigation of Raw Cells Treated With Dextran-Based Magnetic Fluid
Author :
Lacava, Zulmira G M ; Lacava, Leandro M. ; Fonseca, Marcio J P ; Souza, Thiago M M ; Pereira, Luciana O. ; Silva, Osni ; Pelegrini, Fernando ; Sabolovic, Domagoj ; Sestier, Claude ; Azevedo, Ricardo ; Buske, Norbert ; Morais, Paulo C.
Author_Institution :
Inst. de Biologia, Univ. de Brasilia
Abstract :
In the present study, magnetic resonance (MR) and light microscopy (LM) were used to investigate in vitro effects of dextran-coated magnetic nanoparticles (MNPs) on mouse Raw cells. LM showed the increasing internalization and metabolization of MNPs. MR allowed determination of fundamental parameters, such as the MNP internalization half-life (t1/2). The data evidenced that MR can be used as a key spectroscopic technique to investigate MNP internalization and cell/tissue interaction processes in biological systems
Keywords :
cellular biophysics; magnetic fluids; magnetic particles; magnetic resonance spectroscopy; nanoparticles; optical microscopy; cell-particle interaction; dextran; light microscopy; magnetic fluids; magnetic resonance; magnetite nanoparticle; raw cells; Biological systems; Biological tissues; Cells (biology); In vitro; Magnetic force microscopy; Magnetic liquids; Magnetic resonance; Mice; Nanoparticles; Spectroscopy; Cell-particle interaction; Raw cells; magnetic fluid; magnetic resonance; magnetite nanoparticle;
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2006.879448
