Title :
Nonlinear filtering for the estimation of glycated hemoglobin in the presence of fetal hemoglobin using microcolumn ion-exchange chromatography
Author_Institution :
Sch. of Electr. & Electron. Eng., Nanyang Technol. Univ., Singapore
fDate :
5/1/1996 12:00:00 AM
Abstract :
An improved method based on nonlinear least-squares to estimate the percentage concentration of glycated hemoglobin levels HbA1ab, HbA1c, HbF, and other Hb variants is presented. If the existing method is enhanced with the improved method, the use of microcolumn ion-exchange chromatography for estimating glycated hemoglobin levels even for patients with elevated fetal hemoglobin (HbF) would provide a more realistic estimate.
Keywords :
biomedical measurement; blood; chemical variables measurement; chromatography; filtering theory; ion exchange; least squares approximations; patient diagnosis; proteins; Hb variants; HbA1ab; HbA1c; HbF; diabetic patients; elevated fetal hemoglobin; fetal hemoglobin; glycated hemoglobin estimation; long-term glycaemic control; microcolumn ion-exchange chromatography; nonlinear filtering; nonlinear least-squares; percentage concentration; Blood; Costs; Curve fitting; Diabetes; Filtering; Monitoring; Newton method; Performance analysis; Postal services; Resins; Chromatography, Ion Exchange; Fetal Hemoglobin; Filtration; Hemoglobin A, Glycosylated; Humans; Least-Squares Analysis; Nonlinear Dynamics;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
