DocumentCode :
79358
Title :
Multiscale modelling of coupled Ca2+ channels using coloured stochastic Petri nets
Author :
Fei Liu ; Heiner, Monika
Author_Institution :
Control & Simulation Center, Harbin Inst. of Technol., Harbin, China
Volume :
7
Issue :
4
fYear :
2013
fDate :
Aug-13
Firstpage :
106
Lastpage :
113
Abstract :
Stochastic modelling of coupled Ca2+ channels is a challenge, especially when the coupling of the channels, as the authors address this problem using coloured stochastic Petri nets (SPNC) as high-level description to generate determined by their spatial arrangement relative to each other, has to be considered at multiple spatial scales. In this study, continuous-time Markov chains. The authors develop several models with increasing complexity. They first apply SPNC to model single clusters of coupled Ca2+ channels arranged in a regular or irregular lattice, where they describe how to represent the geometrical arrangement of Ca2+ channels relative to each other using colours. They then apply this modelling idea to construct more complex models by modelling spatially arranged clusters of channels. The authors´ models can be easily reproduced and adapted to different scenarios.
Keywords :
Markov processes; Petri nets; bioelectric phenomena; biomembrane transport; coloured stochastic Petri nets; complexity; continuous time Markov chain; coupled calcium ion channel; geometrical arrangement; multiscale modelling; spatial arrangement; stochastic modelling;
fLanguage :
English
Journal_Title :
Systems Biology, IET
Publisher :
iet
ISSN :
1751-8849
Type :
jour
DOI :
10.1049/iet-syb.2012.0017
Filename :
6577286
Link To Document :
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