Title :
Incomplete Lineage Sorting: Consistent Phylogeny Estimation from Multiple Loci
Author :
Mossel, Elchanan ; Roch, Sebastien
Author_Institution :
Dept. of Stat., Univ. of California, Berkeley, CA, USA
Abstract :
We introduce a simple computationally efficient algorithm for reconstructing phylogenies from multiple gene trees in the presence of incomplete lineage sorting, that is, when the topology of the gene trees may differ from that of the species tree. We show that our technique is statistically consistent under standard stochastic assumptions, that is, it returns the correct tree given sufficiently many unlinked loci. We also show that it can tolerate moderate estimation errors.
Keywords :
bioinformatics; estimation theory; genetics; stochastic processes; estimation errors; incomplete lineage sorting; multiple gene trees; multiple loci; phylogeny estimation; stochastic assumptions; Biology and genetics; Incomplete lineage sorting; Probability and Statistics; coalescent process; phylogenetics; population genetics; statistical consistency.; topological concordance; Algorithms; Animals; Chromosome Mapping; Computer Simulation; Evolution; Humans; Linkage Disequilibrium; Models, Genetic; Phylogeny;
Journal_Title :
Computational Biology and Bioinformatics, IEEE/ACM Transactions on
DOI :
10.1109/TCBB.2008.66