Title :
Examining coding structure and redundancy in DNA
Author_Institution :
Center for Signal & Image Process., Georgia Inst. of Technol., Atlanta, GA, USA
Abstract :
A review of DNA signal content, redundancy, and mutational mechanisms is presented. Mutation-robust methods are developed to detect a linear coding structure and approximate tandem repeats. In this article, a method to uncover an error-correction coding structure in the nucleotide sequence is developed and its efficiency in detecting approximate tandem repeats, such as microsatellite regions, is demonstrated.
Keywords :
DNA; error correction codes; molecular biophysics; molecular configurations; reviews; DNA mutation; DNA redundancy; DNA signal content; approximate tandem repeats; error-correction coding structure; linear coding structure; mutation-robust methods; review; Amino acids; DNA; Genetic mutations; Humans; Protection; Proteins; Redundancy; Sequences; Stability; Uncertainty; Animals; Computational Biology; DNA; DNA Damage; DNA Repair; Genetic Code; Humans; Information Storage and Retrieval; Information Theory; Models, Genetic; Systems Biology; Variation (Genetics);
Journal_Title :
Engineering in Medicine and Biology Magazine, IEEE
DOI :
10.1109/MEMB.2006.1578665
