Title :
Detecting structure in parity binary sequences
Author :
Gonzalez, Diego Luis ; Giannerini, Simone ; Rosa, Rodolfo
Author_Institution :
Laboratorio di acustica musicale e architettonica, CNR-Fondazione Scuola di S. Giorgio, Venezia, Italy
Abstract :
In this article, we investigate the possible existence of error-detection/correction mechanisms in the genetic machinery by means of a recently proposed coding strategy. On this basis, we numerically code exons, creating binary parity strings and successively we study their dependence structure by means of rigorous statistical methods (moving block bootstrap, and a new entropy-based method). The results show that parity sequences display complex dependence patterns enforcing the hypothesis of the existence of deterministic error-correction mechanisms grounded on this particular parity coding.
Keywords :
binary codes; entropy; error correction codes; error detection codes; genetics; molecular biophysics; statistical analysis; binary parity strings; complex dependence patterns; entropy; error correction; error detection; exons; genetics; moving block bootstrap; parity binary sequences; parity coding; rigorous statistical methods; structure detection; Binary sequences; Biological information theory; Communication systems; DNA; Error correction; Error correction codes; Genetic communication; Information theory; Proteins; Redundancy; Animals; Base Sequence; Computational Biology; DNA; DNA Damage; DNA Repair; Genetic Code; Humans; Information Storage and Retrieval; Models, Genetic; Molecular Sequence Data; Systems Biology; Variation (Genetics);
Journal_Title :
Engineering in Medicine and Biology Magazine, IEEE
DOI :
10.1109/MEMB.2006.1578666