Title :
In vivo pressure estimation using subharmonic contrast microbubble signals: proof of concept
Author :
Forsberg, Flemming ; Liu, Ji-Bin ; Shi, William T. ; Furuse, Junji ; Shimizu, Masafumi ; Goldberg, Barry B.
Author_Institution :
Dept. of Radiol., Thomas Jefferson Univ., Philadelphia, PA, USA
fDate :
4/1/2005 12:00:00 AM
Abstract :
Changes in ambient pressure affects the reflectivity of ultrasound contrast microbubbles leading to an excellent correlation between subharmonic signals and hydrostatic pressure. The aortas of two dogs were scanned with an experiment pulse-echo system to validate in vivo pressure estimation based on subharmonic microbubble signals. Results matched well with instantaneous pressure measurements (from 20-60 mmHg) obtained simultaneously with a pressure catheter (root mean square errors <27%).
Keywords :
biomedical ultrasonics; bubbles; hydrostatics; pressure measurement; ultrasonic equipment; ultrasonic measurement; ambient pressure; aorta; hydrostatic pressure; instantaneous pressure measurements; pressure catheter; pressure estimation; pulse-echo system; reflectivity; subharmonic contrast microbubble signals; ultrasound contrast microbubbles; Bandwidth; Frequency estimation; In vivo; Pressure measurement; Pulse amplifiers; Pulse generation; Scattering; Shape; Transducers; Ultrasonic imaging; Algorithms; Animals; Aorta; Blood Pressure Determination; Contrast Media; Dogs; Echocardiography; Feasibility Studies; Ferric Compounds; Image Enhancement; Image Interpretation, Computer-Assisted; Iron; Microbubbles; Oxides; Reproducibility of Results; Sensitivity and Specificity;
Journal_Title :
Ultrasonics, Ferroelectrics, and Frequency Control, IEEE Transactions on
DOI :
10.1109/TUFFC.2005.1428040
