DocumentCode :
813996
Title :
Grammatical inference in bioinformatics
Author :
Sakakibara, Yasubumi
Author_Institution :
Dept. of Biosciences & Informatics, Keio Univ., Yokohama, Japan
Volume :
27
Issue :
7
fYear :
2005
fDate :
7/1/2005 12:00:00 AM
Firstpage :
1051
Lastpage :
1062
Abstract :
Bioinformatics is an active research area aimed at developing intelligent systems for analyses of molecular biology. Many methods based on formal language theory, statistical theory, and learning theory have been developed for modeling and analyzing biological sequences such as DNA, RNA, and proteins. Especially, grammatical inference methods are expected to find some grammatical structures hidden in biological sequences. In this article, we give an overview of a series of our grammatical approaches to biological sequence analyses and related researches and focus on learning stochastic grammars from biological sequences and predicting their functions based on learned stochastic grammars.
Keywords :
biology computing; grammars; inference mechanisms; molecular biophysics; stochastic processes; DNA; RNA; bioinformatics; biological sequence analyses; formal language theory; grammatical inference; intelligent systems; learning theory; molecular biology; statistical theory; stochastic grammars; Bioinformatics; Biological system modeling; DNA; Formal languages; Intelligent systems; Protein engineering; RNA; Sequences; Stochastic processes; Systems biology; Index Terms- Grammatical inference; bioinformatics; hidden Markov model; molecular biology; stochastic context-free grammar.; Algorithms; Artificial Intelligence; Cluster Analysis; Computer Simulation; Information Storage and Retrieval; Models, Statistical; Natural Language Processing; Numerical Analysis, Computer-Assisted; Pattern Recognition, Automated; Sequence Alignment; Sequence Analysis; Signal Processing, Computer-Assisted;
fLanguage :
English
Journal_Title :
Pattern Analysis and Machine Intelligence, IEEE Transactions on
Publisher :
ieee
ISSN :
0162-8828
Type :
jour
DOI :
10.1109/TPAMI.2005.140
Filename :
1432739
Link To Document :
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