CMOS DNA Sensor Array With Integrated A/D Conversion Based on Label-Free Capacitance Measurement

Author

Stagni, Claudio ; Guiducci, Carlotta ; Benini, Luca ; Riccò, Bruno ; Carrara, Sandro ; Samorí, Bruno ; Paulus, Christian ; Schienle, Meinrad ; Augustyniak, Marcin ; Thewes, Roland

Author_Institution

DEIS, Bologna Univ.

Volume

41

Issue

12

fYear

2006

Firstpage

2956

Lastpage

2964

Abstract

This paper presents a fully electronic label-free DNA chip in 0.5-mum CMOS technology, with 5-V supply voltage, suitable for low-cost highly integrated applications. The chip features an array of 128 sensor sites with gold electrodes and integrated measurement, conditioning, multiplexing and analog-to-digital conversion circuitry. The circuits measure capacitance variations due to DNA hybridization on the gold electrodes which are bio-modified by covalently attaching probes of known sequence. Specificity, repeatability and parallel detection capability of the fabricated chip are successfully demonstrated

Keywords

CMOS integrated circuits; DNA; analogue-digital conversion; biosensors; capacitance measurement; sensor arrays; 0.5 micron; 5 V; CMOS DNA sensor array; DNA hybridization; analog-to-digital conversion circuitry; biosensors; gold electrodes; integrated A/D conversion; integrated measurement; label-free capacitance measurement; multiplexing; CMOS technology; Capacitance measurement; Capacitive sensors; DNA; Electrodes; Gold; Integrated circuit measurements; Integrated circuit technology; Semiconductor device measurement; Sensor arrays; Biosensors; DNA sensor arrays; capacitance measurement; label-free detection;

fLanguage

English

Journal_Title

Solid-State Circuits, IEEE Journal of

Publisher

ieee

ISSN

0018-9200

Type

jour

DOI

10.1109/JSSC.2006.884867

Filename

4014638