Title :
Hall Biosensor With Integrated Current Microstrips for Control of Magnetic Beads
Author :
Kumagai, Yoshimichi ; Togawa, Kiyoshi ; Sakamoto, Satoshi ; Abe, Masanori ; Handa, Hiroshi ; Sandhu, Adarsh
Author_Institution :
Dept. of Electr. & Electron. Eng., Tokyo Inst. of Technol.
Abstract :
Magnetic labeling of biomolecules shows potential as an alternative to fluorescence for monitoring molecular interactions associated with DNA hybridization and antibody-antigen analysis. Current carrying microstrips were integrated with micro-Hall biosensors to manipulate and collect superparamagnetic beads by field gradients generated due to direct currents passed through the strips. Magnetic beads with 2.8-mum diameters were collected over the active regions of AlGaAs/InGaAs heterostructure micro-Hall biosensors and detected in real time. The integration of current-carrying microstrips with Hall biosensors will decrease the time required for detecting biomolecular recognition processes in Hall sensor-based bioscreening platforms
Keywords :
Hall effect devices; III-V semiconductors; aluminium compounds; biosensors; gallium arsenide; indium compounds; magnetoresistive devices; microsensors; 2.8 micron; AlGaAs-InGaAs; DNA hybridization; Hall biosensor; antibody-antigen analysis; integrated current microstrips; molecular interactions monitoring; supermagnetic beads; Biosensors; DC generators; DNA; Fluorescence; Labeling; Magnetic analysis; Microstrip; Molecular biophysics; Monitoring; Strips; Bioscreening; Hall effect; superparamagnetic beads;
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2006.879613
