DocumentCode :
842881
Title :
Long-term stimulation and recording with a penetrating microelectrode array in cat sciatic nerve
Author :
Branner, Almut ; Stein, Richard B. ; Fernandez, Eduardo ; Aoyagi, Yoichiro ; Normann, Richard A.
Author_Institution :
Dept. of Bioeng., Univ. of Utah, Salt Lake City, UT, USA
Volume :
51
Issue :
1
fYear :
2004
Firstpage :
146
Lastpage :
157
Abstract :
We studied the consequences of long-term implantation of a penetrating microelectrode array in peripheral nerve over the time course of 4-6 mo. Electrode arrays without lead wires were implanted to test the ability of different containment systems to protect the array and nerve during contractions of surrounding muscles. Treadmill walking was monitored and the animals showed no functional deficits as a result of implantation. In a different set of experiments, electrodes with lead wires were implanted for up to 7 mo and the animals were tested at 2-4 week intervals at which time stimulation thresholds and recorded sensory activity were monitored for every electrode. It was shown that surgical technique highly affected the long-term stimulation results. Results between measurement sessions were compared, and in the best case, the stimulation properties stabilized in 80% of the electrodes over the course of the experiment (162 days). The recorded sensory signals, however, were not stable over time. A histological analysis performed on all implanted tissues indicated that the morphology and fiber density of the nerve around the electrodes were normal.
Keywords :
bioelectric phenomena; microelectrodes; neuromuscular stimulation; prosthetics; 162 day; 2 to 4 week; 4 to 6 month; Pb; cat sciatic nerve; functional neuromuscular stimulation; histological analysis; implanted tissues; lead wires; long-term implantation; long-term stimulation; muscle contractions; nerve fiber density; nerve morphology; neuroprosthesis; penetrating microelectrode array; peripheral nerve; recording; sensory activity; treadmill walking; Animals; Electrodes; Legged locomotion; Microelectrodes; Monitoring; Muscles; Protection; Surgery; System testing; Wires; Action Potentials; Animals; Cats; Electric Stimulation; Electromyography; Equipment Failure Analysis; Locomotion; Microelectrodes; Monitoring, Ambulatory; Muscle, Skeletal; Prosthesis Implantation; Sciatic Nerve;
fLanguage :
English
Journal_Title :
Biomedical Engineering, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9294
Type :
jour
DOI :
10.1109/TBME.2003.820321
Filename :
1254004
Link To Document :
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