Title :
A new method to destruct targeted cells using magnetizable beads and pulsed magnetic force
Author :
Ogiue-Ikeda, Mari ; Sato, Yuko ; Ueno, Shoogo
Author_Institution :
Dept. of Biomed. Eng., Univ. of Tokyo, Japan
Abstract :
We investigated a new method to destruct targeted cells using magnetizable beads and pulsed magnetic force. The cells were combined with the beads by an antigen-antibody reaction (cell/bead/antibody complex), aggregated by a magnet, and stimulated by a magnetic stimulator. The viability of the aggregated and stimulated cell/bead/antibody complexes was significantly decreased, and the cells were destructed by the penetration of the beads into the cells or rupturing of the cells by the beads. These results suggest that magnetic aggregation and pulsed magnetic stimulation can effectively damage only the cells targeted by an antigen-antibody reaction.
Keywords :
biological effects of fields; biomagnetism; cancer; cellular biophysics; patient treatment; antigen-antibody reaction; cancer cells; magnetic stimulator; magnetizable beads; pulsed magnetic force; targeted cell destruction; Biomedical engineering; Cancer; Coils; Iron; Magnetic fields; Magnetic forces; Magnetic materials; Magnetic stimulation; Mice; Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Radiation; Ferric Compounds; Humans; Immunomagnetic Separation; Leukemia, Myeloid; Magnetics; Microspheres; Radiation Dosage; Radiometry; Stress, Mechanical; Treatment Outcome;
Journal_Title :
NanoBioscience, IEEE Transactions on
DOI :
10.1109/TNB.2003.820276
