Title :
Multiobjective Optimization in Bioinformatics and Computational Biology
Author :
Handl, Julia ; Kell, Douglas B. ; Knowles, Joshua
Author_Institution :
Manchester Univ.
Abstract :
This paper reviews the application of multiobjective optimization in the fields of bioinformatics and computational biology. A survey of existing work, organized by application area, forms the main body of the review, following an introduction to the key concepts in multiobjective optimization. An original contribution of the review is the identification of five distinct "contexts," giving rise to multiple objectives: These are used to explain the reasons behind the use of multiobjective optimization in each application area and also to point the way to potential future uses of the technique
Keywords :
biology computing; optimisation; reviews; bioinformatics; computational biology; multiobjective optimization; reviews; Association rules; Bioinformatics; Computational biology; Databases; Design for experiments; Design optimization; Genomics; Inverse problems; Machine learning; Proteins; Global optimization; bioinformatics (genome or protein) databases.; classification and association rules; clustering; experimental design; interactive data exploration and discovery; machine learning; Algorithms; Artificial Intelligence; Computational Biology; Gene Expression Profiling; Models, Biological; Pattern Recognition, Automated; Sequence Analysis;
Journal_Title :
Computational Biology and Bioinformatics, IEEE/ACM Transactions on
DOI :
10.1109/TCBB.2007.070203
