Synthesis of Ibuprofen Loaded Magnetic Solid Lipid Nanoparticles

Ibuprofen loaded magnetic solid lipid nanoparticles (Ib-MSLNs) were successfully fabricated using a two-step method: 1)preparation of a warm O/W microemulsion (aqueous surfactant solution with a lipid phase, containing Ibuprofen, stearic acid, 1-octadecanol and lecithin) in which modified lipophilic magnetite (Fe₃O₄) nanoparticles were incorporated, and 2)formation of MSLNs by dispersing the warm microemulsion in cold water under mechanical stirring. The Ib-MSLNs were characterized by transmission electron microscopy, X-ray powder diffraction (XRD), and superconducting quantum interference device (SQUID) magnetometer. TEM and XRD results showed that SLN nanoparticles embedded with magnetic nanoparticles was successfully formed. SQUID measurements indicated that Ib-MSLN exhibited superparamagnetic behavior with a blocking temperature of 98 K. The encapsulation efficiency was measured by high pressure liquid chromatography (HPLC). The magnetite-loaded solid lipid nanoparticles can be potentially used in drug targeting and controlled releasing.