Surface Functionalized Biocompatible Magnetic Nanospheres for Cancer Hyperthermia

Author

Liu, Xianqiao ; Novosad, Valentyn ; Rozhkova, Elena A. ; Chen, Haitao ; Yefremenko, Volodymyr ; Pearson, John ; Torno, Michael ; Bader, Sam D. ; Rosengart, Axel J.

Author_Institution

Dept. of Neurosurg., Chicago Univ. Pritzker Sch. of Medicine, IL

Volume

43

Issue

6

fYear

2007

fDate

6/1/2007 12:00:00 AM

Firstpage

2462

Lastpage

2464

Abstract

We report a simplified single emulsion (oil-in-water) solvent evaporation protocol to synthesize surface functionalized biocompatible magnetic nanospheres by using highly concentrated hydrophobic magnetite (gel) and a mixture of poly(D,L lactide-co-glycolide) (PLGA) and poly(lactic acid-block-polyethylene glycol-maleimide) (PLA-PEG-maleimide) (10:1 by mass) polymers. The as-synthesized particles are approximately spherical with an average diameter of 360-370 nm with polydispersity index of 0.12-0.18, are surface-functionalized with maleimide groups, and have saturation magnetization values of 25-40 emu/g. The efficiency of the heating induced by 400-kHz oscillating magnetic fields is compared for two samples with different magnetite loadings. Results show that these nanospheres have the potential to provide an efficient cancer-targeted hyperthermia.

Keywords

biomagnetism; biomedical materials; cancer; hyperthermia; magnetic particles; magnetisation; nanobiotechnology; nanoparticles; polymer blends; 400 kHz; Fe₂O₃; cancer hyperthermia; hydrophobic magnetite; maleimide groups; poly(D,L lactide-co-glycolide); poly(lactic acid-block-polyethylene glycol-maleimide); polydispersity; polymers; saturation magnetization; single emulsion solvent evaporation; surface functionalized biocompatible magnetic nanospheres; Cancer; Heating; Hyperthermia; Magnetic fields; Magnetic particles; Polymer gels; Saturation magnetization; Scanning electron microscopy; Solvents; Temperature; Hyperthermia; magnetite; nanomedicine; nanospheres; surface functionalization;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2007.894004

Filename

4202969