Title :
Estimation of plasma insulin from plasma glucose
Author :
Neatpisarnvanit, Chatchai ; Boston, John Robert
Author_Institution :
Dept. of Electr. Eng., Mahidol Univ., Bangkok, Thailand
Abstract :
Two plasma insulin estimators are derived and evaluated in this paper. The estimators use continuously monitored plasma glucose, and they are based on a simple mathematical model of glucose-insulin metabolism. The first estimator (Estimator 1) was obtained from the glucose subsystem of the simplified model, which includes plasma glucose and interstitial insulin compartments. The second estimator (Estimator 2) was developed from the insulin kinetics subsystem of the simplified model. The performances of the estimators were compared using computer simulations and data from clinical intravenous glucose tolerance test procedures and from animal experiments.
Keywords :
biochemistry; blood; least mean squares methods; parameter estimation; physiological models; Bergman model; computer simulations; continuously monitored plasma glucose; diabetic model; glucose subsystem; glucose-insulin metabolism; insulin kinetics subsystem; insulin therapy; interstitial insulin compartments; intravenous glucose tolerance test; mathematical model; metabolic parameter assessment; minimal model; nonlinear least-squares; nonlinear model; plasma insulin estimators; Biochemistry; Computer simulation; Insulin; Kinetic theory; Mathematical model; Monitoring; Performance evaluation; Plasma simulation; Sugar; Testing; Animals; Blood Glucose; Blood Glucose Self-Monitoring; Computer Simulation; Dogs; Glucose Tolerance Test; Humans; Insulin; Models, Biological; Models, Cardiovascular; Models, Chemical; Nonlinear Dynamics; Reproducibility of Results; Sensitivity and Specificity; Signal Processing, Computer-Assisted; Stochastic Processes;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2002.804599
