Effects of local variations in skull and scalp thickness on EEG´s and MEG´s

The results of a computer modeling study are reported. They indicate that local variations in skull and scalp thickness have effects on electroencephalograms (EEGs) and magnetoencephalograms (MEGs) which range from a simple intuitive effect to complex effects which depend on such factors as source depth and orientation, the geometry of the variation in skull and scalp thickness, etc. These results also indicate that local variations in skull and scalp thickness cause EEG localization errors which are generally much less than 1 cm and MEG localization errors which are even smaller. These results also indicate that multichannel and single-channel MEG measurements will produce localization errors of approximately the same amplitude when there is a bump on the external surface of the head but that multichannel measurements will produce significantly smaller localization errors than single-channel measurements when a depression is present in that surface.