Laser ablation of atherosclerotic blood vessel tissue under various irradiation conditions

Author

Esenaliev, Rinat O. ; Oraevsky, Alexander A. ; Letokhov, Vladilen S.

Author_Institution

Inst. of Spectrosc., Acad. of Sci., Troitsk, USSR

Volume

36

Issue

12

fYear

1989

Firstpage

1188

Lastpage

1194

Abstract

A quantitative analysis of the destruction of normal wall and atherosclerotic plaque areas of blood vessels by laser radiation is presented. Threshold values of laser radiant exposure were measured experimentally in vitro, along with the ablation efficiency for various laser wavelengths and irradiation conditions. Correlations were found between the ablation efficiency and fluence thresholds on the one hand and the optical properties of the blood vessel tissues on the other. Fibrous plaque was demonstrated to be selectively destroyed by the second-harmonic output from a pulsed Nd:YAG laser at lambda =532 nm.

Keywords

biological effects of laser radiation; blood; solid lasers; 532 nm; YAG:Nd; YAl5O12:Nd; ablation efficiency; atherosclerotic blood vessel tissue; atherosclerotic plaque areas; blood vessels; fibrous plaque; fibrous plaque destruction; fluence thresholds; in vitro; irradiation conditions; laser ablation; laser radiant exposure; laser radiation; laser wavelengths; normal wall; pulsed Nd:YAG laser; second-harmonic output; vessel tissues; Angioplasty; Biomedical optical imaging; Blood vessels; Fiber lasers; In vitro; Laser ablation; Laser modes; Laser theory; Neodymium; Optical pulses; Solid lasers; Wavelength measurement; Aorta, Thoracic; Arteriosclerosis; Humans; Laser Therapy; Light; Optics; Scattering, Radiation;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/10.42113

Filename

42113