Chemical and Biological Applications of Digital-Microfluidic Devices

Author

Fair, Richard B. ; Khlystov, Andrey ; Tailor, Tina D. ; Ivanov, Vladislav ; Evans, Randall D. ; Griffin, Peter B. ; Srinivasan, Vijay ; Pamula, Vamsee K. ; Pollack, Michael G. ; Zhou, Jack

Author_Institution

Duke Univ., Durham, NC

Volume

24

Issue

1

fYear

2007

Firstpage

10

Lastpage

24

Abstract

Digital-microfluidic lab-on-a chip (LoC) technology offers a platform for developing diagnostic applications with the advantages of portability, sample and reagent volume reduction, faster analysis, increased automation, low power consumption, compatibility with mass manufacturing, and high throughput. In addition to diagnostics, digital microfluidics is finding use in airborne chemical detection, DNA sequencing by synthesis, and tissue engineering. In this article, we review efforts to develop various LoC applications using electrowetting-based digital microfluidics. We describe these applications, their implementation, and associated design issues.

Keywords

DNA; bioMEMS; biological techniques; lab-on-a-chip; microfluidics; molecular biophysics; reviews; tissue engineering; DNA sequencing; airborne chemical detection; biological application; chemical application; diagnostic application; digital-microfluidic device; electrowetting; lab-on-a chip technology; reagent volume reduction; review; tissue engineering; Chemical engineering; Chemical processes; Chemical technology; Electrodes; Lab-on-a-chip; Manufacturing automation; Microfluidics; Performance analysis; Throughput; Tissue engineering; analysis; detection; digital microfluidics; electrowetting; lab on a chip; sample collection;

fLanguage

English

Journal_Title

Design & Test of Computers, IEEE

Publisher

ieee

ISSN

0740-7475

Type

jour

DOI

10.1109/MDT.2007.8

Filename

4212064